2024-03-28T19:59:49Zhttp://aquadocs.org/oai/requestoai:aquadocs.org:1834/11392021-05-19T06:13:58Zcom_1834_17815com_1834_17387com_1834_1337col_1834_17816col_1834_5156
An antimalarial cembranolide from Tanzania soft corals, Lobophytum crassum (von Marenzeller (1886) and L. rotundum (Tixier-Durivault (1957).
Said, S.A.
Lobophytum crassum
L. rotundum
Plasmodium falciparum
Antimalarial
Soft corals
Cytotoxicity
Cembranolide
Parasites
Parasites
Coral reefs
Brine shrimp eggs
Bioscreening guided fractionation of the extracts of soft corals Lobophytum crassum and L. rotundum using brine shrimp larvae cytotoxicity assay led to the isolation of a cembranolide diterpene (E,E,E)-6,10,14-trimethyl-3-methylene- 3a,4,7,8,11,12,15,15aoctahydrocylotetradeca [b]furan-2(3H)-one (1). This diterpene, identified as cembranolide compound 1, was found to be active against the multidrug-resistant and chloroquine-sensitive strains of Plasmodium falciparum malaria parasite in vitro. It also possessed cytotoxic properties.
Published
2006-02-08T11:25:56Z
2006-02-08T11:25:56Z
2005
Journal Contribution
Refereed
Article
Western Indian Ocean Journal of Marine Science, 4 (1), p. 95–98
0856-860X
http://hdl.handle.net/1834/1139
en
http://www.wiomsa.org
58999 bytes
application/pdf
WIOMSA