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Please use this identifier to cite or link to this item:
http://hdl.handle.net/1834/3866
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| Title: | Acanthifoliosides, minor steroidal saponins from the Caribbean marine sponge Pandaros acanthifolium |
| Authors: | Regalado, E.L.
Jiménez-Romero, C.
Genta-Jouve, G.
Tasdemir, D.
Amade, P.
Nogueiras, C.
Thomas, O.P. |
| ASFA Terms: | Sponges |
| Issue Date: | 2011 |
| Citation: | Tetrahedron, 67. p. 1011-1018 |
| Abstract: | Seven novel steroid glycosides, acanthifoliosides A-F (1-6) and the methyl ester of 6 (7), were
isolated from the marine sponge Pandaros acanthifolium as minor components.
Acanthifoliosides are characterized by a rare C-15 and C-16 oxidized D ring which was
previously found in saponins produced by starfishes. Very uncommon is the presence of
additional sugar residues at C-15 or C-16. Their structures were determined on the basis of
extensive spectroscopic analyses, including two-dimensional NMR and HRESIMS data. The
absolute configurations of the aglycones were assigned by comparison between experimental
and TDDFT calculated CD spectra of 1, whereas the absolute configurations of the
monosaccharide units were determined by chiral GC analyses of the acid methanolysates. Some
of the acanthifoliosides exhibit moderate antiprotozoal activity but to a lesser extent than the
most potent pandarosides. |
| URI: | http://hdl.handle.net/1834/3866 |
| Related document: | http://dx.doi.org/10.1016/j.tet.2010.11.103 |
| Appears in Collections: | 1. Articulos científicos
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