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Please use this identifier to cite or link to this item: http://hdl.handle.net/1834/3865

Title: Repair of UVB-Damaged Skin by the antioxidant sulphated flavone glycoside Thalassiolin B Isolated from the marine plant Thalassia testudinum Banks ex König
Authors: Regalado, E.L.
Rodríguez, M.
Menéndez, R.
Concepción, A.A.
Nogueiras, C.
Laguna, A.
Rodríguez, A.A.
Williams, D.E.
Lenzo-Luaces, P.
Valdés, O.
Hernandez, Y.
ASFA Terms: Chemistry
Pharmacology
Issue Date: 2009
Citation: Marine biotechnology, 11(1). p. 74-80
Abstract: Daily topical application of the aqueous ethanolic extract of the marine sea grass, Thalassia testudinum, on mice skin exposed to UVB radiation resulted in a dose dependent recovery of the skin macroscopic alterations over a 6-day period. Maximal effect (90%) occurred at a dose of 240 μg/cm2, with no additional effects at higher doses. Bioassay-guided fractionation of the plant extract resulted in the isolation of thalassiolin B (1). Topical application of 1 (240 μg/cm2) markedly reduces skin UVB-induced damage. In addition, thalassiolin B scavenged 2,2-diphenyl-2-picrylhydrazyl radical with an EC50=100 μg/ml. These results suggest that thalassiolin B is responsible for the skin regenerating effects of the crude extract of T. testudinum
URI: http://hdl.handle.net/1834/3865
Related document: http://www.springerlink.com/content/x325587654j918...
Appears in Collections:1. Articulos científicos

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