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Please use this identifier to cite or link to this item:
http://hdl.handle.net/1834/3865
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| Title: | Repair of UVB-Damaged Skin by the antioxidant sulphated flavone glycoside Thalassiolin B Isolated from the marine plant Thalassia testudinum Banks ex König |
| Authors: | Regalado, E.L.
Rodríguez, M.
Menéndez, R.
Concepción, A.A.
Nogueiras, C.
Laguna, A.
Rodríguez, A.A.
Williams, D.E.
Lenzo-Luaces, P.
Valdés, O.
Hernandez, Y. |
| ASFA Terms: | Chemistry
Pharmacology |
| Issue Date: | 2009 |
| Citation: | Marine biotechnology, 11(1). p. 74-80 |
| Abstract: | Daily topical application of the aqueous ethanolic extract of the marine sea grass, Thalassia
testudinum, on mice skin exposed to UVB radiation resulted in a dose dependent recovery of the
skin macroscopic alterations over a 6-day period. Maximal effect (90%) occurred at a dose of 240
μg/cm2, with no additional effects at higher doses. Bioassay-guided fractionation of the plant extract
resulted in the isolation of thalassiolin B (1). Topical application of 1 (240 μg/cm2) markedly reduces
skin UVB-induced damage. In addition, thalassiolin B scavenged 2,2-diphenyl-2-picrylhydrazyl
radical with an EC50=100 μg/ml. These results suggest that thalassiolin B is responsible for the skin
regenerating effects of the crude extract of T. testudinum |
| URI: | http://hdl.handle.net/1834/3865 |
| Related document: | http://www.springerlink.com/content/x325587654j918... |
| Appears in Collections: | 1. Articulos científicos
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