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Please use this identifier to cite or link to this item: http://hdl.handle.net/1834/3860

Title: Polar Alkaloids from the Caribbean Marine Sponge Niphates digitalis
Authors: Regalado, E.L.
Mendiola, J.
Laguna, A.
Nogueiras, C.
Thomas, O.P.
ASFA Terms: Sponges
Cytotoxicity
Issue Date: 2010
Citation: Natural Produts Communications, 5(8). p. 1187-1190
Abstract: A method involving flash chromatography, semi-preparative phenylhexyl RP HPLC-DAD-ELSD combined with analytic polar-RP HPLC-DAD, was applied to separate and purify six highly nitrogenated bases and a bicyclic amidine alkaloid, the major components of the marine sponge Niphates digitalis. Their structures were identified as 1,8-diazabicyclo[5.4.0]undec-7- ene (1), deoxycytidine (2), phenylalanine (3), adenosine (4), deoxyguanosine (5), adenine (6) and thymidine (7) on the basis of spectroscopic data analyses. This is the first report of these compounds in a marine sponge belonging to the Niphates genus and the first evidence of the presence of 1 from a natural source.
URI: http://hdl.handle.net/1834/3860
Related document: http://pubget.com/paper/20839615
Appears in Collections:1. Articulos científicos

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