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Please use this identifier to cite or link to this item:
http://hdl.handle.net/1834/3661
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| Title: | The marine plant thalassia testudinum possesses anti-inflammatory and analgesic properties |
| Authors: | Llanio, M.
Fernández, M.D.
Cabrera, B.
Bermejo, P.
Abad, M.J.
Payá, M.
Alcaraz, M.J. |
| Issue Date: | 2006 |
| Citation: | Pharmacologyonline, (3). p. 594-600 |
| Abstract: | The natural marine compounds represent a source of new
chemical structures and of pharmacological substances with
anti-inflammatory activity that will allow to deep in the
knowledge of the inflammatory process and in novel
mechanisms of action of therapeutic agents. In this work we
carry out the study of a extract of a marine plant present in the
Cuban coast, Thalassia testudinum (Tt) with the objective of
detecting anti-inflammatory and analgesic effects by
carrageenan paw oedema, croton oil mouse ear oedema,
phospholipase A2 (PLA2) inhibition, cyclo-oxygenase (COX)
inhibition and writhing tests. Three fractions, obtained from
this extract, were also evaluated in the assay of croton oilinduced
ear oedema, PLA2 inhibition, COX inhibition and
writhing test.
The extract obtained from the Tt plant demonstrated an
inhibitory effect in the carrageenan paw oedema. Also,
demonstrated inhibitory effect over PLA2 and COX enzyme.
Chloroform and butanolic fractions also inhibited mouse ear
oedema assay, and COX enzyme, but only the chloroform
fraction inhibited the PLA2 enzyme. The extract, butanolic and
aqueous fractions inhibited writhing test. We can conclude that
the extract, chloroform and butanol fractions shows antiinflammatory
properties and the extract and two of the
fractions show analgesic effect. |
| URI: | http://hdl.handle.net/1834/3661 |
| Appears in Collections: | 1. Articulos científicos
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