Immunosuppressive effects of metrifonate on oreochromis niloticus
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Date
2005
Metadata
Show full item recordAlternative Title
التأثيرات المثبطة للمناعة للميتروفونات على البلطى النيلىAbstract
The effect of metrifonate on the immunity of the exposed fish are evaluated through the determination of the antibody titer and mortality rate during the challenge trial. In the chronic toxic exposure to metrifonate by dose 0.17mg/liter for 8 weeks, the more clear signs were darkness of fish color with hemorrhagic patches & loosing of scale at end of the trial the color return to normal. Determination of some blood parameters revealed significant decrease of white blood cell count, as there were lymphopenia and nueutrophilia during the chronic exposure to metrifonate. Phagocytic assay revealed a significant decrease in both phagocytic activity (PA) and phagocytic index(PI).Hypoproteinami hypoglobulinaemia and hypoalbuminaemia were observed. The challenge trial indicted that, the metrifonate decrease the immunity of exposed fish.. The using of biogen“R” as a growth promoter in fish diet minimized the toxicity of metrifonate.Journal
Egyptian Journal of Aquatic ResearchVolume
31Issue/Article Nr
1Publisher or University
Alexandria: National Institute of Oceanography and Fisheries