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Please use this identifier to cite or link to this item: http://hdl.handle.net/1834/1218

Title: Immunosuppressive effects of metrifonate on oreochromis niloticus
Other Titles: التأثيرات المثبطة للمناعة للميتروفونات على البلطى النيلى
Authors: Soliman, M.K.
Mohamed, S.G.
El-Gohary, M.S.
Khalil, R.H.
El-Banna, S.
ASFA Terms: Biology
Immunology
Issue Date: 2005
Publisher: Alexandria: National Institute of Oceanography and Fisheries
Citation: Egyptian Journal of Aquatic Research, 31 (1), p. 448 - 458
Abstract: The effect of metrifonate on the immunity of the exposed fish are evaluated through the determination of the antibody titer and mortality rate during the challenge trial. In the chronic toxic exposure to metrifonate by dose 0.17mg/liter for 8 weeks, the more clear signs were darkness of fish color with hemorrhagic patches & loosing of scale at end of the trial the color return to normal. Determination of some blood parameters revealed significant decrease of white blood cell count, as there were lymphopenia and nueutrophilia during the chronic exposure to metrifonate. Phagocytic assay revealed a significant decrease in both phagocytic activity (PA) and phagocytic index(PI).Hypoproteinami hypoglobulinaemia and hypoalbuminaemia were observed. The challenge trial indicted that, the metrifonate decrease the immunity of exposed fish.. The using of biogen“R” as a growth promoter in fish diet minimized the toxicity of metrifonate.
Description: This journal is published by NIOF, Alexandria, Egypt
URI: http://hdl.handle.net/1834/1218
ISSN: 1110-0354
Appears in Collections:Egyptian Journal of Aquatic Research
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